Mehta, Rahul C.,Makino, Elizabeth Tsin Ho,Sonti, Sujatha D.,Garruto, John A.
申请号：
AU2016201597
公开号：
AU2016201597A1
申请日:
2016.03.11
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016201597A120160331.pdf#####MELANIN MODIFICATION COMPOSITIONS AND METHODS OF USE ABSTRACT A method for the modification of melanin distribution, and the composition thereof to modify melanin distribution are disclosed. A method for the reduction of melanin distribution, and the composition thereof to reduce melanin distribution are disclosed. A representative composition comprises 4-ethoxybenzaldehyde and one or more additional active agents as well as a pharmaceutically acceptable carrier or excipient. Carriers and excipients may be formulated for topical administration. Compositions may also be formulated for transdermal administration. The compositions may be used for the prevention and treatment of pigmentation disorders, by way of non-limited example, post-inflammatory hyperpigmentation and others. The compositions may be used for lightening skin.WO 2012/094638 PCT/US2012/020550 7/9 FIG. 7 Significant Reduction in Hyperpigmentation 100 C .A 9 -0-4% Hydroquinone m = 95 -a-Base +0.5% 4EB S o 90 85 C 80 U- 75 70 P<；O.001 compared to baseline for every time point 0 4 8 12 Weeks
