Kit Oleg Ivanovich,Shikhlyarova Alla Ivanovna,Frantsiyants Elena Mikhajlovna,Zhukova Galina Vitalevna,Cheryarina Natalya Dmitrievna,Barteneva Tatyana Albertovna,Protasova Tatyana Panteleevna,Shirnina Elena Alekseevna,Kurkina Tatyana Anatolevna,Bragina Marina Igorevna
申请号：
RU20170124784
公开号：
RU2670656(C1)
申请日:
2017.08.30
申请国别(地区):
俄罗斯
年份:
2018
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention relates to experimental medicine, namely to experimental oncology, and can be used to predict tumor growth in an experiment. Method of prediction consists in that white mongrel rats or rats of the Wistar line grafted into the subcutaneous tissue of the pelvic region of the back of the Guerin carcinoma reached a volume of 0.25 cm, conduct therapeutic chemotherapy. Use cyclophosphamide at a dose of 50 mcg/kg twice with an interval of 5 days in combination with oral administration of 2 drops of 3 times a day 0.01 % cAMP solution. At the stage of effect realization, the level of cAMP is determined in tumor tissue. And at a cAMP level of 0.75±0.2 nmol/l predict tumor regression, and at a cAMP level of 7.03±1.05 nmol/l predict a tumor progression.EFFECT: method ensures reliability of predicting tumor growth, which is important for assessing the effectiveness of treatment and timely correction of this treatment.1 cl, 1 tbl, 4 dwg
