This application relates to a pharmaceutical composition for the treatment and / or prevention of cancer comprising a polynucleotide derived from miRNA associated with cancer as an active ingredient, a pharmaceutical combination of this pharmaceutical composition with another antitumor agent, and these A method for treating or preventing a subject having cancer using the pharmaceutical composition or the combination pharmaceutical of the present invention is provided.この出願は、癌と関連するmiRNAを由来とするポリヌクレオチドを有効成分として含む癌の治療及び/又は予防用医薬組成物、この医薬組成物と別の抗腫瘍剤との組み合わせ医薬品、並びに、これらの医薬組成物又は組み合わせ医薬品を用いて癌をもつ被験体を治療又は予防する方法を提供する。