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WAYS OF STRENGTHENING STABILIZATION OF ALPHA FACTOR-1 INDUCED BY HYPOXIA
专利权人:
АЭРПИО ТЕРАПЬЮТИКС ИНК. (US)
发明人:
ШАЛВИЦ Роберт (US),ГАРДНЕР Джозеф Х. (US)
申请号:
RU2012123386/15
公开号:
RU2012123386A
申请日:
2010.11.05
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. The use of a compound or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for enhancing HIF-1 stabilization in a cell, wherein the compound has the formula: wherein L is selected from CH or SO; R is 0 to 5 hydrogen substituents; n is an integer a number from 0 to 5; each R and R are independently selected from: i) hydrogen; ii) substituted or unsubstituted C-C linear, C-C branched or C-Cyclic alkyl; iii) substituted or unsubstituted C-C linear, C-C branched or C-Cyclic alkenyl; iv) substituted or not Clineynogo-substituted or C-C-Crazvetvlennogo alkynyl; v) substituted or unsubstituted Sealy Carila; vi) substituted or unsubstituted C-Cgeterotsikla; vii) substituted or unsubstituted C-Cgeteroarila; or viii) R and R, taken together, can form a substituted or unsubstituted heterocyclic or substituted or unsubstituted heteroaryl ring containing from 2 to 20 carbon atoms and from 1 to 7 heteroatoms. 2. The use of a compound or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for enhancing an immune response in a subject, wherein the compound has the formula: in which L is selected from CH or SO; R is from 0 to 5 hydrogen substituents; index n is an integer from 0 to 5; each R and R is independently selected from: i) hydrogen; ii) substituted or unsubstituted C-C-linear, C-C-branched or C-Cyclic alkyl; iii) substituted or unsubstituted C-C-linear, C-C-branched or C-Cyclic alkenyl; iv) substituted or not ameschennogo Clineynogo or C-C-Crazvetvlennogo alkynyl; v) substituted or unsubstituted Sealy Carila; vi) substituted or unsubstituted C-Cgeterotsikl1. Применение соединения или его фармацевтически приемлемой соли для получения лекарственного средства для усиления HIF-1 стабилизиции в клетке, где соединение имеет формулу:в которой L выбран из CHили SO;R представляет собой от 0 до 5 заместителей водорода;индекс n представляет собой целое число от 0 до 5;каждый Rи Rнезависимо выбран из:i) водорода;ii) замещенного
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