Process for the preparation of highly O-sulfated, epimerized derivatives of K5 polysacchride and intermediates therein

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专利权人:

发明人:

Pasqua Anna Oreste,Giorgio Zoppetti

申请号：

US14328271

公开号：

US09346893B2

申请日:

2014.07.10

申请国别(地区):

US

年份:

2016

代理人:

摘要：

A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.

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中国工程科技知识中心

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