The present invention relates to compositions and methods for treatingdiseases and disorders including cancer and various other angiogenic-dependentdiseases, vascular malfunctions, arteriovenous malformations (AVM),hemorrhagic processes and treatment of pain, in particular tumor-related painby drug delivery and/or therapeutic embolization using microspheres. Moreparticularly the invention relates to microspheres containing non-ioniccontrast agents, to compositions comprising these microspheres, as well asmethods for preparing and using such compositions for embolization therapy.The invention further relates to compositions and methods using detectablemicrospheres for targeted drug delivery, irrespective of whether embolizationis also needed.