ВАН ДЕР ЛЕ Миранда Мария Корнелия (NL),АРИАНС Герардус Йозеф Андреас (NL),СХАУТЕН Ян (NL),БЛОМЕНРОХР Марион (NL),ГРОТХЕЙС Патрик Герхард (NL),КАУМАНС Руди Герардус Элизабет (NL)
申请号：
RU2018122629
公开号：
RU2018122629A
申请日:
2016.11.24
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
The present disclosure relates to CDR defined antibodies targeting the 5T4 oncofoetal antigen (TPBG, 5T4, Wnt Activated Inhibitory Factor 1, WAIF1) which exhibit a binding affinity for human 5T4 antigen which is in the same order of magnitude as their affinity for cynomolgus monkey 5T4. Antibody-drug conjugates (ADCs), and their use in the treatment of human solid tumours and haematological malignancies are claimed.
