Described herein are pharmaceutical compositions for the oral administration of mesalazine, as well as methods of making such pharmaceutical compositions, and therapeutics methods for using them. The compositions comprise delayed-immediate release and delayed-extended release formulation of mesalazine.本案描述用於經口投予美沙拉的醫藥組成物,以及製造所述醫藥組成物的方法,以及使用其之治療方法。所述組成物包含美沙拉之延遲-立即釋放和延遲-延長釋放調配物。