Hadas Sara HERSHKOVICH;Catherine BRAMI;Carsten HAGEMANN;Tali VOLOSHIN-SELA;Carola FORSTER;Mario LOHR;Almuth F. KESSLER;Malgorzata BUREK
发明人:
Carsten HAGEMANN,Mario LOHR,Almuth F. KESSLER,Malgorzata BUREK,Carola FORSTER,Catherine BRAMI,Hadas Sara HERSHKOVICH,Tali VOLOSHIN-SELA
申请号：
US16548537
公开号：
US20200061361A1
申请日:
2019.08.22
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.
