Nuesch, Jurg,Thomas, Nadja,Plotzky, Claudia,Rommelaere, Jean
申请号：
AU2011250204
公开号：
AU2011250204B2
申请日:
2011.05.09
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Described are (a) parvovirus variants capable of propagating and spreading through human tumor cells which is obtainable by serially passaging a rodent parvovirus as starting strain in semi-permissive human tumor cells, and (b) parvovirus variants capable of propagating and spreading through human tumor cells characterized by particular amino acid deletions and/or substitutions, e.g. a deletion of several amino acids in the C-terminus of NS1/middle exon of NS2. A pharmaceutical composition containing such parvoviruses as well as their use for the treatment of cancer, preferably a glioblastoma, is also described.
