Stefan I. McDonough;Justin K. Murray;Leslie P. Miranda
发明人:
Justin K. Murray,Leslie P. Miranda,Stefan I. McDonough
申请号：
US14005135
公开号：
US20140073577A1
申请日:
2012.03.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted Nav1.7 inhibitor. In some disclosed embodiments, the isolated polypeptide is an inhibitor of Nav1.7 and/or Nav1.3. Other embodiments are conjugated embodiments of the inventive composition of matter and pharmaceutical compositions containing the inventive composition of matter. Isolated nucleic acids encoding some embodiments of inventive polypeptides and expression vectors, and recombinant host cells containing them are disclosed. A method of treating or preventing pain is also disclosed.
