BIOPHOSPHONATE COMPOUNDS AND GAMMA DELTA T CELL-MEDIATED THERAPY FOR TREATING EPSTEIN-BARR VIRUS-ASSOCIATED DISORDERS

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专利权人:

发明人:

Wenwei Tu,Zheng Xiang,Yinping Liu

申请号：

US14824316

公开号：

US20160045521A1

申请日:

2015.08.12

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Aminobisphosphonate pamidronate (PAM) can control Epstein-Barr virus (EBV) associated disorders in humanized mice through a Vγ9Vδ2-T-cell dependent mechanism. This suggests a strong potential for a therapeutic approach using PAM to boost human Vγ9Vδ2-T-cell immunity against EBV associated disorders, such as the lymphoproliferative disease (LPD), posttransplant lymphoproliferative disorder (PLPD), Hodgkins disease, Burkitts lymphoma, and nasopharyngeal carcinoma (NPC).

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中国工程科技知识中心

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http://www.ckcest.cn/home/