Pyrimidine derivatives as PI-3 kinase inhibitors农业专利-农业学术服务平台

发明人:: T．皮克,P．巴尔桑尼,P．巴爾桑尼,E．伊瓦什凯维奇,E．伊瓦什凱維奇,W．范特尔,W．范特爾,T．亨德里克森,M．纳普,M．納普,H．梅里特,C．沃尔特娃,C．沃爾特娃,M．维斯曼,M．維斯曼,X．辛,M．比尔热,M．比爾熱,Z．倪,S．佩基,G．阿塔略,S．巴尔图利斯,S．巴爾圖利斯,K．弗雷泽,K．弗雷澤,A．史密,T.皮克,P.巴尔桑尼,P.巴爾桑尼,E.伊瓦什凯维奇,E.伊瓦什凱維奇,W.范特尔,W.范特爾,T.亨德里克森,M.纳普,M.納普,H.梅里特,C.沃尔特娃,C.沃爾特娃,M.维斯曼,M.維斯曼,X.辛,M.比尔热,M.比爾熱,Z.倪,S.佩基,G.阿塔略,S.巴尔图利斯,S.巴爾圖利斯,K.弗雷泽,K.弗雷澤,A.史密

摘要：: The present invention discloses -3 kinase inhibitor compounds (I) of phosphatidylinositols (PI), its pharmaceutically acceptable salt and its prodrug； The composition of the noval chemical compound, the composition individually contain the compound or also contain at least one other therapeutic component and pharmaceutically acceptable carrier； The purposes of noval chemical compound is used alone or is applied in combination at least one other therapeutic component, prevents or treat proliferative disease with what, the disease characteristic is in what growth factor, the abnormal activity of Protein Serine/threonine kinase and phospholipid kinases.本發明公開磷脂酰肌醇(PI)-3激酶抑制劑化合物(I)、其藥學上可接受的鹽及其前藥；該新化合物的組合物，該組合物單獨含有該化合物或者還含有至少一種其它治療成分以及藥學上可接受的載體；新化合物的用途，單獨使用或者與至少一種其它治療成分組合使用，用於預防或治療增生性疾病，所述疾病特徵在於生長因子、蛋白絲氨酸/蘇氨酸激酶和磷脂激酶的異常活性。