The invention is in the area of pleuripotent stem cells generated from adiposetissue-derived stromal cells and uses thereof. In particular, the inventionincludes isolated adipose tissue derived stromal cells that have been inducedto express at least one phenotypic characteristic of a neuronal, astroglial,hematopoietic progenitor, or hepatic cell. The invention also includes anisolated adipocyte tissue-derived stromal cell that has been dedifferentiatedsuch that there is an absence of adipocyte phenotypic markers.