PIKKEMAAT JEROEN A,LANGEREIS SANDER,GRUELL HOLGER,BURDINSKI DIRK,LAMERICHS RUDOLF M J N,KEUPP JOCHEN
申请号：
IN5035/CHENP/2011
公开号：
IN2011CN05035A
申请日:
2011.07.13
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The invention relates to a method of MR imaging of at least a portion of a body of a patient placed in an examination volume of an MR device. The object of the invention is to improve CEST contrast enhanced imaging. The method of the invention comprises the following steps: a) saturation of nuclear magnetization of exchangeable protons of a CEST contrast agent administered to the patient by subjecting the portion of the body to at least one frequency-selective saturation RF pulse matched to the MR frequency of exchangeable protons of the CEST contrast agent, wherein the saturation period, i.e. the duration of the frequency-selective saturation RF pulse, is shorter than the time required for saturation to build up a full CEST contrast enhancement effect when starting from zero saturation b) generating at least one MR signal of water protons of the body by subjecting the portion of the body to an MR imaging sequence comprising at least one RF pulse and switched magnetic field gradients c) acquiring and sampling the at least one MR signal from the body d) repeating steps a) to c) a number of times under variation of parameters of the MR imaging sequence, wherein MR signals are acquired and sampled during a saturation build-up period, i.e. before a steady state of the CEST effect is achieved e) reconstructing a proton-density weighted, CEST contrast-enhanced MR image from the acquired and sampled MR signals.
