SOON-SHIONG, PATRICK,NIAZI, KAYVAN,SIELING, PETER,LAZAR, ADAM
申请号：
CA3058144
公开号：
CA3058144A1
申请日:
2018.03.26
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Contemplated treatment compositions and methods are directed to co-administration of sensitized genetically modified NK cells and recombinant IL-12, wherein the genetically modified NK cells were preferably sensitized by constitutive exposure to IL-2 and wherein the IL-12 is expressed from a recombinant virus or given as an IL-12-antibody conjugate. Such treatment increases IFN? secretion by the sensitized NK cells, and advantageously also increases expression of NKG2D.
