THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人:
MAO, JEREMY
申请号：
EP08796132
公开号：
EP2175803A4
申请日:
2008.07.10
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The common premise of synthetic implants in the restoration of diseased tissues and organs is to use inert and solid materials. Here, a porous titanium implant enables the delivery of microencapsulated bioactive cues. Control-released TGF&bgr；1 promoted the proliferation and migration of human mesenchymal stem cells into porous implants in vitro. Upon 4-wk implantation in the rabbit humerus, control-released TGF&bgr；1 from porous implants significantly increased BIC by 96% and bone ingrowth by 50% over placebos. Control-released 100 ng TGF&bgr；1 induced equivalent BIC and bone ingrowth to adsorbed 1 &mu；g TGF&bgr；1, suggesting that controlled release is effective at 10-fold less drug dose than adsorption. Histomorphometry, SEM and &mu；T showed that control-released TGF&bgr；1 enhanced bone ingrowth in the implant's pores and surface. These findings suggest that solid prostheses can be transformed into porous implants to serve as drug delivery carriers, from which control-released bioactive cues augment host tissue integration.
