Robert John Zagursky,Amy Wadhams Masi,Bruce Arthur Green,Deb Narayan Chakravarti,David Parrish Russell,Joseph Lawrence Wooters
申请号：
US13546761
公开号：
US20130011428A1
申请日:
2012.07.11
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of Streptococcus pneumoniae, wherein the open reading frames encode polypeptides that are surface localized on Streptococcus pneumoniae. Thus, the invention relates to Streptococcus pneumoniae open reading frames that encode polypeptides encoded by the Streptococcus pneumoniae open reading frames, vectors comprising open reading frame sequences and cells or animals transformed with these vectors. The invention relates also to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Streptococcus pneumoniae infection. The invention finally relates to pharmaceutical compositions, in particular immunogenic compositions, for the prevention and/or treatment of bacterial infection, in particular infections with Streptococcus pneumoniae.
