synthetic peptide for use in biological tests for the detection of infections due to the group o hiv1 virus, its composition, in vitro immunoassay and diagnostic kit.
DENIS MARIE BERNARD CHENEBAUX,JEAN-FRANCOIS HUBERT DELAGNEAU,STEPHANE JEAN XAVIER GADELLE,FRANCOIS YVES RIEUNIER
申请号：
BR9809078
公开号：
BR9809078B1
申请日:
1998.04.06
申请国别(地区):
BR
年份:
2012
代理人:
摘要：
Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I): <；?in-line-formulae description="In-line Formulae" end="lead"?>；Delta-Z-TrpGlyCys-Theta-CysTyrThrSer-Omega (I)<；?in-line-formulae description="In-line Formulae" end="tail"?>； wherein Delta is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH<；SUB>；3<；/SUB>；CO-) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -Xi<；SUB>；1<；/SUB>；-Ser-Xi<；SUB>；2<；/SUB>；-, -Xi<；SUB>；1<；/SUB>；-Gln-Xi<；SUB>；2<；/SUB>；-, or -Xi<；SUB>；1<；/SUB>；-Asn-Xi<；SUB>；2<；/SUB>；-, wherein -Xi<；SUB>；1 <；/SUB>；represents a peptide sequence of 0 to 9 amino acids and -Xi<；SUB>；2 <；/SUB>；represents a peptide sequence of 0 to 5 amino acids, Theta is -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile- (SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), Omega, attached to the -CO- group of serine, is a hydroxyl (-OH) radical, an amino (-NH<；SUB>；2<；/SUB>；) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-Sigma-Psi wherein Sigma represents a sequence of formula -(AA<；SUB>；1<；/SUB>；)-Trp Asn-(AA<；SUB>；2<；/SUB>；)-(AA<；SUB>；3<；/SUB>；) wherein (AA<；SUB>；1<；/SUB>；) represents an amino acid different from lysine, (AA<；SUB>；2<；/SUB>；) represents an amino acid, and (AA<；SUB>；3<；/SUB>；) is serine or a threonine residue, and Psi, attached to the -CO- residue of the free AA<；SUB>；3 <；/SUB>；amino acid, is OH, NH<；SUB>；2<；/SUB>；, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of
