Novel compounds

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专利权人:

Mission Therapeutics Limited

发明人:

Kemp, Mark Ian,Stockley, Martin Lee,Madin, Andrew

申请号：

AU2016373533

公开号：

AU2016373533A1

申请日:

2016.12.16

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C- terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein R

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