This invention relates to combination therapies targeting two or all of PD-1, TIM-3, and LAG-3 using antibodies specific for these targets in patients who are in need of enhanced immunity. Also included in the invention are compositions useful in the therapies. The therapies are useful in treating diseases such as cancers.本發明係關於使用專一於PD-1、TIM-3、及LAG-3之二者或所有者的抗體於需要提高免疫力的患者中靶向此等目標的組合療法。亦包括於本發明中者係可用於此等療法中的組成物。此等療法可用於治療諸如癌症的疾病。