n-acyl- (3-substituted) - (8-substituted) -5,6-dihydro- [1,2,4] triazol [4,3a] pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor mediated disorders

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专利权人:

EUROSCREEN S.A.

发明人:

GRAEME FRASER,GUILLAUME DUTHEUIL,HAMID HOVEYDA

申请号：

BR112015024907

公开号：

BR112015024907A2

申请日:

2014.03.28

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary “n-acyl- (3-substituted) - (8-substituted) -5,6-dihydro- [1,2,4] triazole [4,3a] pyrazines as selective nk-3 receptor antagonists , pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders The present invention relates to novel compounds of formula I and their use in treatments Therapeutic1/1 resumo “n-acil-(3-substituido)-(8-substituido)-5,6-dihidro-[1,2,4]triazol[4,3­a]pirazinas como antagonistas receptores seletivos de nk-3, composição farmacêutica, métodos para uso em desordens mediadas por receptores de nk-3” a presente invenção está relacionada a novos compostos de fórmula i r1 o r4 r2 * nn n n r3 r1' r2' x2 n x1 r5 e o seu uso em tratamentos terapêuticos.

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