The present request relates to useful compounds that destroy, inhibit and prevent the growth or recreation of cells, especially malignant cells, in peripheral tissues involving various human and animal diseases. Claim 1: a compound of formula (1) or an acceptable salt in the formula, wherein: R1,R2,R83088 and r83099 were selected from hydrogen, heterocycle and cyano-cf832303, respectively；-NRR； - Oh； - halogen； - selective tar group, replaced by one or more groups selected from heterocycle, - NRR, - o r and one dissolution group； optional alcox group, replaced by one or more groups selected from heterocycle, - NRR, - or and one dissolution group； - co-nrr； - so83222-nrr； - nr-co-r and so8322r； R and R are independent of hydrogen, cyclopropyl, heterocycle, dissolving group and selective tar group, respectively, and are replaced by one or more selected or, NRR, nrcor and dissolving group； R and R are independent of hydrogen, tar and cyclopropyl, respectively； R3 is hydrogen.A is an aperiodic group, which can be replaced by one or more selected halogen, tar, arilo, hydroxy, Alcoy, nitrogen, sulfur, isocyclopentyl, heterogeneous, cyanogen, cyclopentyl, soluble, NRR, tar NRR, nr-co-r, coir and so-83222 groups； Where R and R are selected respectively, regardless of hydrogen, tar, cyclopropyl, arilo, isopropyl and heteromorphic； B is arilo or heteromorphic； X is n or c-r8310；R8310 is selected from hydrogen, cyanogen and cf832323；1. Pitch and alcoxi； the condition is that B is not selected from 1.2 diazo, trinitropyridine or trinitroformate； if B is oxazolilo, a is not butyl tetraformate or tetrahydropyridine； if B is thiazole, a is not pyridinopyridin, triamate, pyridinopyridin, pyridinediol or 1.4-oxazil.La presente solicitud se relaciona con compuestos útiles para destruir, inhibir, o evitar el crecimiento o el esparcimiento de células, en especial de células malignas, dentro de los tejidos circundantes implicadas en una variedad de enfermedades humanas y animales. Rei
