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INHIBITORS OF SIALOADHESIN FOR THE TREATMENT OF DISEASES CAUSED BY ENVELOPED VIRUSES
专利权人:
LABORATORIOS DEL DR. ESTEVE; S.A.
发明人:
Nuria Izquierdo Useros,Hans-Georg Krauesslich,Maier Lorizate,Javier Martinez Picado
申请号:
US14366839
公开号:
US20140370052A1
申请日:
2012.12.17
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention refers to methods and compositions to prevent viral entry into cells expressing the CD169/sialoadhesin surface receptor by inhibiting the coupling of the sialyllactose molecule contained in the viral membrane gangliosides to the CD 169/sialoadhesin receptor. The invention also pertains to vaccine compositions based on dendritic cells loaded with an antigen of interest whereby the vaccine is provided together with a composition capable of preventing viral entry into cells expressing the CD169/sialoadhesin. Moreover, the invention relates to diagnostic and therapeutic compositions that can be specifically delivered to enveloped virions wherein the diagnostic/therapeutic agent is coupled to CD169/sialoadhesin.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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