Devices and Systems for Optically Determining a Concentration of an Analyte in a Living Subject Using Hydrogel-Based, Fluorescent Microneedles and Methods of Manufacture Thereof
The Trustees of Columbia University in the City of New York
发明人:
Samuel K. SIA,Matthieu Jean Michel RUEEGG,Nalin TEJAVIBULYA
申请号：
US15554406
公开号：
US20180177439A1
申请日:
2016.03.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
At least one microneedle comprises a hydrogel material that includes a substance that fluoresces when the substance interacts with an analyte. A magnitude of the fluorescence varies as a function of the concentration of the analyte. During use, the hydrogel material is illuminated with illumination light in a first wavelength range while the hydrogel material interfaces with the dermal interstitial fluid layer of a subject, and a photosensor generates an output that corresponds to an amount of light received in a second wavelength range.
