Compositions comprising polyethylene glycol (PEG) are disclosed for the prophylaxis and/or treatment of head and neck squamous cell carcinomas (HNSCC). Methods for the prophylaxis and/or treatment of HNSCC comprising administering an effective amount of PEG are also disclosed. Also disclosed are methods and compositions for suppressing the surface expression of EGFR using PEG.本發明揭示用於預防及/或治療頭頸部鱗狀細胞癌(HNSCC)之包含聚乙二醇(PEG)之組成物。亦揭示用於預防及/或治療HNSCC之方法,該方法包含投予有效量之PEG。亦揭示使用PEG抑制EGFR之表面表現的方法及組成物。