PURPOSE: An antibiotics composition containing plant or extract thereof against pathogenic microorganism is provided to treat pig, cow, sheep, chicken, and horse without side effects. CONSTITUTION: An antibiotics composition against clostridium perfringens type E contains Curcuma domestica Valeton or the extract thereof as an active ingredient. The extract is obtained using water or organic solvent. The organic solvent is methanol, ethanol, propanol, butanol, benzene, toluene, hexane, or acetone, The composition is used for treating or preventing enterotoxemia.본 발명은 식물 또는 그 추출물을 유효성분으로 포함하는 병원성 미생물에 대한 항생용 조성물, 그 제조방법 및 상기 조성물의 사료에 응용에 관한 것이다.