LARSON, ALYSSA M.,LOVE, KEVIN,WEIGHT, ALISHA K.,CRANE, ALAN,LANGER, ROBERT S.,KLIBANOV, ALEXANDER M.
申请号：
CA2923844
公开号：
CA2923844A1
申请日:
2014.09.11
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous (SC) or intramuscular (IM) injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and organophosphates. The viscosity of the formulation is significantly reduced by the addition of one or more organophosphates.
