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Crystals of Dispiropyrrolidine Derivatives
专利权人:
发明人:
Shoko YOSHIDA,Yuuichi SUGIMOTO
申请号:
US15887648
公开号:
US20180155356A1
申请日:
2018.02.02
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3′R,4′S,5′R)—N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″-oxo-1″,2″-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indole]-5′-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same.
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