NARQUIZIAN ROBERT,PINARD EMMANUEL,POLARA ALESSANDRA,ROGERS-EVANS MARK,WOLTERING THOMAS,HILPERT HANS,WOSTL WOLFGANG
申请号：
NZ61609912
公开号：
NZ616099A
申请日:
2012.05.11
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
The present invention provides compounds of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer&rsquo；s disease and type 2 diabetes. Examples of the compounds for formula (I) are: (S)-4-{ S-[(4-Chloro-l-difluoromethyl-lH-pyrazol-3-ylmethyl)-amino ]-2-fluoro-phenyl } -4-methyl-S,6-dihydro-4H-[1,3]oxazin-2-ylamine (4R,SR)-4-[S-(Cyclopropylmethyl-amino)-2-fluoro-phenyl]-S-fluoro-4-methyl-S,6-dihydro-4H[1,3]oxazin-2-ylamine 7-[3-((R)-2-Amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluorophenylamino]-6,7-dihydro-5H-[1]pyrindine-3-carbonitrile.
