A pharmaceutical composition includes dorzolamide or a salt thereof and brimonidine or a salt thereof and has a pH of 6.0 or more. The pharmaceutical composition preferably does not include a preservative or includes a prescribed amount thereof, wherein said prescribed amount is preferably such that the common logarithmic value of the ratio (B/A) of the number (B) of bacteria at the time of inoculation to the number (A) of bacteria when the number of viable bacteria is measured after inoculating bacteria in a test sample that consists of the preservative and water and mixing homogeneously such that the concentration of Escherichia Coli ATCC 8739 in the bacterial suspension is within the range of 105-106 cfu/mL, and collecting 1 mL of the test sample using a micropipette after the test sample has been stored for seven days at 20-25° C. while shielded from light, is 2.0 or less.
