A vacuum sealing drainage device for a bleeding wound tissue, includes a multi-hole foam cushion (1) contacted with the bleeding wound tissue, a drainage pipe (2) with a side hole, a sealing film (3), a connector (4), a duct (17), a drainage container (5), and a vacuum source (6). The device further includes a glue film (7) and an leading-out pipe (8). The glue film (7) is disposed above the multi-hole foam cushion (1). An opening of the side hole of the drainage pipe (2) is contacted with the multi-hole foam cushion (1). The leading-out pipe (8) is connected to the drainage pipe (2), and is disposed above the glue film (7). The sealing film (3) is sealed on the glue film (7). The leading-out pipe (8) is received in the drainage container (5) via the duct (17), and the drainage container (5) is connected to the vacuum source (6) via the duct (17). The device increases time of maintaining elasticity and a humid environment for the multi-hole foam cushion, which is helpful for wound healing. The sealing and drainage thereof are convenient and reliable.