PROBLEM TO BE SOLVED: To obtain an antimicrobial agent (antituberculous agent) containing a new antimicrobial active compound as an active ingredient.SOLUTION: This antimicrobial agent, particularly antitberculous agent comprises, as an active ingredient, a pharmacologically permissible ester derivative, ether derivative, N-alkyl derivative of carbamoyl group of a compound represented by the formula (wherein R1 is hydrogen atom or methyl group R2a is hydrogen atom, a protective group of hydrogen group or methyl group R3 is hydrogen atom or a protective group of hydroxyl group R4a is hydrogen atom, hydroxyl group or protected hydroxyl group R5 is hydrogen atom or a protective group of hydroxyl group X is methylene group or sulfur atom) or a pharmacologically permissible salt thereof.COPYRIGHT: (C)2001,JPO【課題】新規抗菌活性化合物を有効成分とする抗菌剤(特に抗結核剤)を提供する。【解決手段】【化1】(式中、R1 は水素原子又はメチル基を示し、R2aは水素原子、水酸基の保護基又はメチル基を示し、R3 は水素原子又は水酸基の保護基を示し、R4aは水素原子、水酸基又は保護された水酸基を示し、R5 は水素原子又は水酸基の保護基を示し、Xはメチレン基又は硫黄原子を示す。)で表わされる化合物の薬理上許容されるエステル誘導体、エーテル誘導体、カルバモイル基のN-アルキル誘導体、又はそれらの薬理上許容される塩を有効成分として含有する抗菌剤、特に抗結核剤。
