Dubensky, Thomas W.,Leong, Meredith Lia Ling,Pardoll, Drew M.,Kim, Young Jun
申请号:
AU2013271375
公开号:
AU2013271375A1
申请日:
2013.06.07
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
The present invention provides a combination therapy which relies on a small molecule immune stimulator - cyclic-di-nucleotide (CDN) - that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes) formulated with allogeneic human tumor cell lines engineered to secrete high amounts of GM-CSF. This combination therapy can provide an ideal synergy of multiple tumor associated antigens, DC recruitment and proliferation, coupled with a potent DC activation stimulus.