GEORGETTE CASTANEDO,JIANWEN FENG,CHRISTIAN A. G. N. MONTALBETTI,STEVEN STABEN
申请号：
ARP130100469
公开号：
AR089999A1
申请日:
2013.02.15
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
The compounds of formula (1) and their pharmaceutical components can be used to treat diseases and disorders, because in this case, it can be found that NF-kB signal is accidentally activated or over activated. Requirement 1: a compound of formula (1), wherein: A1,...A3 and a830808 are composed of the following personnel: A1,...A3 is type N and a83088es C； A1 and A2 are type N, A3 is type C (RA'3), a8308e is type C； A1 is type C, A2 is type N, A3 is type n (RN3) and a8308es C； A1 is type C, A2 is type n (RN2),A³ is N and A⁴ is C, said RN² is hydrogen, C₁₋₃ alkyl,Halogenated tar c83218323；(Alquil C) -C (3DO) - o (haloalquil C) -C (3DO) -A¹ is C and one of A² and A³ is N and the other is S and A⁴ is C； A¹ is C, A² is S, A³ is C (RA³) and A4 is C； A¹ is C, A² is N, A³ and A⁴ is N； A¹ is C, A² is N, A³ is C (RA³) and A⁴ is N； A¹ is C, A² is C (RC²),A³ is S and A⁴ is C, said RC² is hydrogen, halogen, C₁₋₃ alkyl,Halogenated tar c83218323；(Alquil C) -C (3DO) - o (haloalquil C) -C (3DO) -a. A1 is C, A2 and A3, a83088n； a8309a and a8310n are independent of C or N； X is o or C (R1) 8322；M is an integer from 0 to 4, R1,R² and RA³ and RN³ are chosen independently of each occurrence from the group consisting of hydrogen, -F, -Cl, -Br, -I, - (X¹) ₀₋₁-CN, - (X¹) ₀₋₁-NO₂ ,- (X) -SF- (X) -OH - (X) -NH- (X) -N (H) (R)- (X) -N (R) (R)- (X) -CF1. Lease land No. c833218331 and 832626；C₁₋₆ haloalkyl,3. Heterosexual c83218c31832626；C₁₋₆ alkoxy,1. C8332121 asphalt；- (X¹) ₀₋₁-C₁₋₆ alkyl,- (X) -cicloalquilo C- (X¹) ₀₋₁-C₂₋₉ heterocycloalkyl,- (X¹) ₀₋₁-heteroaryl of 5 - 10 links, - (X¹) ₀₋₁-aryl of 6 - 10 links, -C (= O) (X¹) ₁-C₃₋₁₀ cycloalkyl,-C (= O) (x1) c8321o heterosexual c832283331；3DO - (X) -C (3DY) N (H) (R)- (X) -C (3DY) -NH- (X) -C (3DY) -N (R) (R)- (X) -C (3DY) OR- (X) -C (3DY) OH - (X) -N (H) -C (3DY) (R)- (X) -N (R) C (3DY) (R)- (X) -N (R) C (3DY) (H)- (X) -N (H) C (3DY) OR- (X) -N (R) C (3DY) OR- (X) -S (O) R- (X) -N (H) S (O) R- (X) -N (R) S (O) R- (X) -S (O) N (H) (R)- (X) -S
