Fisher, Terrence Lee,Smith, Ernest S.,Zauderer, Maurice
申请号：
AU2013239662
公开号：
AU2013239662B2
申请日:
2013.03.27
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The invention relates to epitopes of SEMA4D and to binding agents, such as antibodies, that specifically bind to SEMA4D. In certain embodiments, the amino acid substitutions are conservative ammo acid substitution, discussed further below. Alternatively, mutations can be introduced randomly along all or part of the coding sequence, such as by saturation mutagenesis, and the resultant mutants can be screened for biological activity to identify mutants that retain activity (e.g., the ability to bind a SEMA4D polypeptide, e.g., human, murine, or both human and murine SEMA4D).
