A device for manufacturing dental prosthesis comprises an articulation cast (2) having at least one supporting portion or wax rim (3) in a plastically yieldable material and provided with an at least partial imprint of the dental arch of the patient which the prosthesis is designed for, a plurality of shaped elements (4, 4) adapted to be removably and adjustably applied to the deformable supporting portion (3), each of them reproducing the profile of a corresponding tooth to simulate a portion of the dental arch of the prosthesis to be manufactured. The shaped elements (4, 4) are arranged into a plurality of series (S, S, S") adapted to be selectively applied to the supporting portion (3), the shaped elements (4, 4) of each series (S, S, S") being joined with each other in side-by-side positions reciprocally aligned along a longitudinal direction (L) by means of a substantially elongated and elastically deformable connecting member (5) adapted to allow the joined application of the shaped elements (4, 4) of the corresponding series (S, S, S") and the regulation of the respective reciprocal positions along at least one predetermined direction.
