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Germanium complexes with amino acids and carboxylic acids and method to prepare the same
专利权人:
Obschestvo S Ogranichennoi Otvetstvennostyu "WDS FARMA"
发明人:
ISAEV, Alexandr Dmitrievich,MANASHEROV, Tamaz Omarovich,AMBROSOV, Igor Valerievich,MATELO, Svetlana Konstantinovna
申请号:
ES12866873
公开号:
ES2634820T3
申请日:
2012.11.09
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A method for preparing complex compounds of germanium with amino acids or with amino acids and carboxylic acids of the general formula Ge [OH] a [AA] b [CA] c (I) in which AA is an amino acid, CA is a carboxylic acid, a>; = 0: 3, b>; = 1: 3, c>; = 0: 3, and 1 <;= b + c <;= 4, and in which all the AAs in the complex compound are the same or different, and all the CAs in the complex compound are the same or different, in which the amino acids are preferably selected from the group containing α-amino acids, for example alanine, aminobutyric acid, arginine, aspartic acid, valine, norvaline, histidine, glycine, glutamic acid, isoleucine, leucine, norleucine, lysine, methionine, ornithine, serine, tyrosine, threonine, tryptophan and phenylalanine; and amino acids that are not α-amino acids, for example α-aminobutyric acid; and carboxylic acids are preferably selected from the group containing monocarboxylic acids such as acetic acid, dichloroacetic acid and isovaleric acid; dicarboxylic acids such as azelaic acid, malonic acid, oxalic acid, phthalic acid, fumaric acid and succinic acid; hydroxycarboxylic acids such as tartaric acid, citric acid, lactic acid and malic acid; hydroxybenzoic acids, for example salicylic acid; and pyridine monocarboxylic acids, for example nicotinic acid, wherein the method comprises: providing an aqueous suspension of α-germanium dioxide; add to the aqueous suspension of α-germanium dioxide at least one amino acid, or at least one amino acid and at least one carboxylic acid; Heat the resulting mixture under stirring at a temperature between 40 and 100 ° C for 2-14 hours, followed by filtration and removal of water to isolate a complex compound from the aqueous solution.Un método para preparar compuestos complejos de germanio con aminoácidos o con aminoácidos y ácidos carboxílicos de la fórmula general Ge[OH]a[AA]b[CA]c (I) en la que AA es un aminoácido, CA es un ácido carboxílico, a >;= 0 : 3, b >;= 1 : 3, c >;= 0 : 3, y 1 <
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