Provided herein are systems, apparatuses and methods for use in disinfecting pneumatic tube system (PTS) components and/or disinfecting air displaced during the operation of a PTS. More specifically, various aspects are directed to the use of light source disinfection systems for disabling bacteria, viruses and/or other micro-organisms (hereafter “pathogens”) in a PTS. The light source disinfection systems allow of cleaning pneumatic carriers, cleaning the interior of pneumatic tubes and PTS components and/or cleaning air, which is used to propel pneumatic carriers in a PTS.