Neil Kerslake Gibbs;Catherine Anne Oneill;Catherine Anne O'neill
发明人:
Catherine Anne O'neill,Neil Kerslake Gibbs,Catherine Anne Oneill
申请号：
US14008469
公开号：
US20140086977A1
申请日:
2012.03.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a new therapy targeted at the restoration or improvement of tight junction function. Aberrant TJ function, is characteristic of many chronic skin diseases. The inventors demonstrated that plant polyphenols or flavonoids and Cis-urocanic acid modulates tight junction structure and function in mammalian keratinocytes and provided tight junction modulators, pharmaceutical compositions and methods for preventing or treating impaired tight junction function in stratified mammalian epithelia.
