A USE OF FERULIC ACID FOR MANUFACTURING DRUGS FOR IMPROVING THE OXYGEN-RELEASING ABILITY OF HEMOGLOBIN TO ORGANS AND PERIPHERAL TISSUES IN HUMAN BODIES
A use of ferulic acid of manufacturing drugs for improving the oxygen-releasing ability of oxygenated hemoglobin to organs and peripheral tissues in human bodies is disclosed. The ferulic acid forms a hydrogen bond with the Val1 residue of the hemoglobin α subunit, thus stabilizing the oxygenated hemoglobin in the low oxygen affinity T form and facilitating the oxygen release to organs and peripheral tissues.一種阿魏酸之用途,係用以製備提升帶氧血紅蛋白釋放氧氣至人體內各器官及周邊組織的能力之藥物,其中,阿魏酸係與血紅蛋白之α次單元的Val1殘基形成一氫鍵,使帶氧血紅蛋白穩定處於低氧親合力並容易釋放氧氣之T態。
