The present invention relates to at least one phosphate binder, at least one uremic toxin binder, at least one blood vessel for the management of progressive kidney disease, including chronic kidney disease (CKD), in domestic carnivores. In particular, the present invention relates to a combination of an agonist antihypertensive agent and at least one antifibrotic agent, and the present invention is directed to a veterinary composition comprising said combination and its use for the treatment of CKD conditions.本発明は、飼育用肉食動物における、慢性腎臓疾患（ＣＫＤ）を含む進行性腎疾患の管理のための、少なくとも１つのリン酸塩結合剤、少なくとも１つの尿毒症毒素結合剤、少なくとも１つの血管作動性血圧降下剤および少なくとも１つの抗線維化剤の組み合わせに関する、特に、本発明は、前記組み合わせを含む獣医用組成物、およびＣＫＤ状態の治療のためのその使用を対象とする。
