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Controlled release tamsulosin tablets
专利权人:
シントン・ベスローテン・フェンノートシャップ
发明人:
レメンス,ヤコブス・マリア,プラッテュー,ヨハネス・ヤン,ファン・ダーレン,フランス,オルテガ,アルトゥーロ・シレス,エスコイ,フアン・クカラ,レメンス,ヤコブス・マリア,プラッテュー,ヨハネス・ヤン,ファン・ダーレン,フランス,オルテガ,アルトゥーロ・シレス,エスコイ,フアン・クカラ
申请号:
JP2010232415
公开号:
JP5536610B2
申请日:
2010.10.15
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
The invention relates to a pharmaceutical tablet comprising a tablet matrix having dispersed therein 0.1 to 10 mg of tamsulosin or a pharmaceutically acceptable salt thereof, and optionally having an enteric coating over said matrix, wherein said tablet is a modified release tablet and has a dissolution profile such that in each of the media SIF, FaSSIF, and FeSSIF, said tablet releases not more than 60% of said tamsulosin at 2 hours elapsed time in USP 2 apparatus using 500 ml of said media at 50-100 rpm paddle speed, to a monolithic pharmaceutical tablet, comprising 0.1 to 10 mg of tamsulosin or a pharmaceutically acceptable salt thereof, 10 wt% - 90 wt% hydroxypropyl methylcellulose, and a total tablet weight of 10 to 300 mg, to a unit dosage form for treating or ameliorating the conditions of benign prostatic hyperplasia comprising an effective amount of one or more tablets as mentioned above, and to a method for treating the symptoms of benign prostatic hyperplasia, which comprises administering to a patient in need thereof one or more tablets as mentioned above.
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