Transforming growth factor beta (TGF-beta ) superfamily production secretion promoter comprises a 5 membered heterocycle derivative (I). TGF-beta superfamily production secretion promoter comprises a 5 membered heterocycle derivative of formula (I) or its salts or prodrugs. [Image] R 1halo or optionally substituted heterocyclyl, hydroxy, thiol or amino； A : optionally esterified or amidated carboxyl or optionally substituted acyl, heterocyclyl or hydroxy； B' : optionally substituted aromatic group； X : O, S or optionally substituted imino, and Y : divalent hydrocarbyl or heterocyclyl. ACTIVITY : Neuroprotective； Uropathic； Auditory； Osteopathic； Antidiabetic； Antiarthritic； Antirheumatic； Endocrine； Nephrotropic； Analgesic； Dermatological. MECHANISM OF ACTION : TGF-beta agonist. In a diabetic neuropathy model in SD rats, administration of 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-[3-(2-methylphenoxy)propyl]oxazole (Ia) at 10 mg/kg/day orally for 4 months increased growth/differentiation factor-15 production to 135% of a control.
