Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
Eickelmann, Peter,Thomas, Leo,Eckhardt, Matthias,Sauer, Achim,Himmelsbach, Frank
申请号：
AU2007247218
公开号：
AU2007247218B2
申请日:
2007.05.02
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Glucopyranosyl- substituted, benzonitrile derivatives defined accordingto formula I, including the tautomers, the stereoisomers thereof, the mixturesthereof and the salts thereof . The compounds according to the invention are suitablefor the treatment of metabolic disorders. formula (I), wherein Rdenoteshydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, propyl, isopropyl,butyl, sec-butyl, iso-butyl, tert-butyl, 3-methyl-but-1-yl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, 1-hydroxy-cyclopropyl, 1-hydroxy-cyclobutyl,1- hydroxy-cyclopentyl, 1 -hydroxy-cyclohexyl, difluoromethyl, trifluoromethyl,pentafluoroethyl,_2-hydroxyl-ethyl, hydroxymethyl, 3-hydroxy-propyl,2-hydroxy-2- methyl-prop-1-yl, 3-hydroxy-3-methyl-but-1-yl, 1-hydroxy-1-methyl-ethyl, 2,2,2- trifluoro-1-hydroxy-1 -methyl-ethyl, 2,2,2-trifluoro-i-hydroxy-i-trifluoromethyl-ethyl,2- methoxy-ethyl, 2-ethoxy-ethyl, hydroxy, difiuoromethyloxy, trifluoromethyloxy,2- methyloxy-ethyloxy, methylsulfanyl, methylsulfinyl, methlysulfonyl,ethylsulfinyl, ethylsulfonyl, trimethylsilyl or cyano,
