NETZ, ASTRID,AMBERG, WILHELM,LANGE, UDO,OCHSE, MICHAEL,HUTCHINS, CHARLES W.,GARCIA-LADONA, FRANCISCO-XAVIER,WERNET, WOLFGANG,KLING, ANDREAS
申请号：
ES05707406
公开号：
ES2494918T3
申请日:
2005.02.15
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Guanidine compound of general formula I corresponding enantiomeric, diastereomeric and / or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof, where the indicated moieties have the following definitions: where A: is halogen, OH, CN, CF3, CHF2, OCF3 , OCHF2, or C1-C6 alkyl or C2-C6 alkenyl, -O-CH2-COO-RA 1, O-RA 1, S-RA 1, NRA 2RA 3, -NRA 4-CO-RA 1, SO2NH2, NRA 4-SO2-RA 1, SO2-NRA 2RA -CO-NRA 4-RA 1 in each case eventually replaced； RA 1: C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, (C1-C4) alkylene-C3-C7 cycloalkyl, (C1-C4) alkylene-heterocycloalkyl, aryl, heteroaryl, heterocycloalkyl, alkylene (C1-C4) -aryl, alkenylene (C2-C6) -aryl or alkylene (C1-C6) -hetaryl in each case optionally substituted； RA 2: hydrogen, OH, CN, or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C1-C4) alkylene-C3-C7 cycloalkyl, (C1-C4) alkylene-heterocycloalkyl, aryl, heteroaryl, heterocycloalkyl, (C1-C4) alkylene, alkyl (C1-C4) -hetaryl, alkylene (C1-C6) -O-C1-C6 alkyl, CO-C1-C6 alkyl, CO-aryl, CO-heteroaryl, CO-alkylene (C1-C4) -aryl, CO-(C1-C4) -heteroyl, CO-O-C1-C6-alkyl, COO-aryl, CO-O-alkylene (C1-C4) -aryl, CO-O-heteroaryl , CO-O-(C1-C4) -hetaryl, SO2-C1-C6-alkyl, SO2-aryl, SO2-heteroaryl, SO2-alkylene (C1-C4) -aryl or SO2-alkylene (C1-C4) -hetaryl in each case eventually replaced； RA 3: C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C1-C4) alkylene-C3-C7 cycloalkyl, (C1-C4) -heterocycloalkyl, aryl, heteroaryl, heterocycloalkyl, (C1-C4) alkylene ) -aryl, (C1-C4) alkylene -hetaryl, (C1-C6) alkylene -O-C1-C6 alkyl, CO-C1-C6 alkyl, CO-aryl, CO-hetaryl, CO-(C1-C4) alkylene , CO-C1-C4 alkylene -hetaryl, CO-O-C1-C6 alkyl, COO-aryl, CO-O-alkylene (C1-C4) -aryl, CO-O-heteroaryl, CO-O-alkylene ( C1-C4) -hetaryl, SO2-C1-C6 alkyl, SO2-aryl, SO2-heteroaryl, SO2-alkylene (C1-C4) -aryl or SO2-alkylene (C1-C4) -hetaryl in each case optionally substituted； or the residues RA 2 and RA 3 together with the nitrogen form a saturated or aromatic heterocycle, optiona
