The Broad Institute, Inc.;The General Hospital Corporation;DANA-FARBER CANCER INSTITUE
发明人:
Marc Wein,Henry Kronenberg,Thomas Sundberg,Ramnik Xavier,Nathanael S. Gray,Yanke Liang,Hwan Geun Choi,Alykhan Shamji
申请号：
US16333546
公开号：
US20200179387A1
申请日:
2017.09.16
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure provides methods of treating and/or preventing osteoporosis using salt-inducible kinase (SIK) inhibitors. Also provided are methods of using SIK inhibitors for increasing the function of osteocytes, increasing the number of osteoblasts, increasing the activity of osteoblasts, inhibiting the resorption of a bone, decreasing the number of osteoclasts, inhibiting the activity of osteoclasts, increasing the mass of a bone, down-regulating the expression of the gene SOST, and/or inhibiting the activity of sclerostin. The SIK inhibitors may be combined with Src inhibitors or CSF I R inhibitors. Exemplary SIK inhibitors include the compounds of the formula: (I), (II), (III), (IV), (V) or (VI).
