PROBLEM TO BE SOLVED: To provide a porcine epidemic diarrhea preventative or therapeutic method, a vaccine kit, a vaccine for oral or nasal administration and a vaccine for intramuscular administration which are excellent in the activity in inducing production of a neutralizing antibody specific to the porcine epidemic diarrhea virus and the activity in inducing a humoral immune response and enable efficient prevention or therapy of porcine epidemic diarrhea.SOLUTION: A preventative or therapeutic method for porcine epidemic diarrhea includes: a first administration step in which a live vaccine for the porcine epidemic diarrhea virus and an adjuvant are administered to pigs either orally or nasally； and a second administration step in which an inactivated vaccine for the porcine epidemic diarrhea virus and an adjuvant are administered to the pigs intramuscularly.SELECTED DRAWING: None【課題】豚流行性下痢ウイルスに特異的な中和抗体の産生誘導活性、及び液性免疫応答の誘導活性に優れ、効率よく豚流行性下痢を予防又は治療することができる豚流行性下痢の予防又は治療方法、ワクチンキット、経口又は経鼻投与用ワクチン、及び筋肉内投与用ワクチンを提供すること。【解決手段】豚流行性下痢ウイルスの生ワクチンとアジュバントとを経口投与及び経鼻投与のいずれかで豚に投与する第１の投与工程と、前記豚流行性下痢ウイルスの不活化ワクチンとアジュバントとを筋肉内投与で前記豚に投与する第２の投与工程と、を含む豚流行性下痢の予防又は治療方法である。【選択図】なし
