GRIESENBACH, UTA,FERRARI, STEFANO,GEDDES, DUNCAN M.,ALTON, ERIC WFW,HASEGAWA, MAMORU,HOU, XIAOGANG
申请号：
CA2428073
公开号：
CA2428073C
申请日:
2001.11.08
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention provides a paramyxovirus vector for gene transfer to thecardiovascular system and uses thereof. The invention enables the efficienttransfer of a foreign gene product to the cardiovascular system by use of theparamyxovirus vector. Products of genes introduced by intranasal orintramuscular administration of the paramyxovirus vector were detected inblood at high levels. The administration of a vector for the expression of theanti-inflammatory cytokine IL-10 inhibited collagen deposition in lung ofpulmonary fibrosis model animal. Thus, the vector of the present invention issuitable for gene transfer to the cardiovascular system.
