LEE CHEN, GUEY JEN,李桂桢,李桂楨,HSIEH, HSIU MEI,谢秀梅,謝秀梅,YAO, CHING FA,姚清发,姚清發
申请号：
TW102119511
公开号：
TW201444555A
申请日:
2013.05.31
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
A use of compound for manufacturing pharmaceutical composition of abnormal polyglutamine-mediated disease is disclosed. The compound can reduce the polyglutamine aggregation through decreasing reactive oxygen species production and increasing the activity of chaperone and autophagy.本發明係有關於一種化合物於製備不正常多麩醯胺(polyglutamine)聚集類疾病之醫藥組成物上之用途,該化合物係透過降低活性氧化物(ROS)含量、活化伴隨蛋白、及增加細胞自噬活性,以達到減少多麩醯胺聚集之目的。
